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Hidden Regulators: Small Noncoding RNAs Redefine Cardiovascular Disease Mechanisms

2025-04-20  |  15:55:05
THESIG1

The classification of tsRNAs. tsRNAs include tiRNA and tRF. Under stress, angiogenin cleavage of the tRNA anticodon loop generates tiRNAs that are further categorized as 5′ tiRNA and 3′ tiRNA.

THESIG2

piRNA biogenesis pathways in drosophila. The biogenesis pathways of piRNA involve primary and secondary pathways.

THESIG3

The categorization of PIWI family proteins. piRNA primarily engages in physiological functions by binding with PIWI proteins within reproductive cells, encompassing family proteins in humans, mice, and drosophila.

SHANNON, CLARE, IRELAND, April 20, 2025 /EINPresswire.com/ --
In a transformative review, small noncoding RNAs (sncRNAs) have emerged as pivotal regulators in the complex landscape of cardiovascular diseases. These RNA molecules, which do not encode proteins, were long overshadowed by their well-studied counterparts such as microRNAs. However, new insights highlight the substantial biological impact of lesser-known sncRNA subclasses including transfer RNA-derived fragments (tsRNAs), PIWI-interacting RNAs (piRNAs), Y RNAs (yRNAs), small nucleolar RNAs (snoRNAs), and small nuclear RNAs (snRNAs).

Each of these RNA types exhibits unique biological functions in modulating gene expression, cell signaling, and physiological homeostasis. Their roles in cardiovascular health are particularly significant as they engage in processes like inflammation, apoptosis, vascular remodeling, and cardiac hypertrophy. For example, tsRNAs influence myocardial cell survival and proliferation, regulate endothelial cell functions, and have been linked to disorders such as myocardial infarction, hypertension, and diabetic cardiomyopathy. They serve as critical responders to cellular stress, modulating gene transcription and mitochondrial pathways that can protect cardiac tissue.

Meanwhile, piRNAs have advanced from their original association with reproductive biology to being recognized as influential actors in cardiovascular systems. These molecules orchestrate cell apoptosis, manage oxidative stress, and mediate gene methylation, impacting disease processes like heart failure, aortic dissection, and pulmonary hypertension. Notably, specific piRNAs such as HAAPIR and CHAPIR are involved in promoting or mitigating cardiac damage through transcriptional and epigenetic mechanisms.

The regulatory potential of yRNAs lies in their interplay with immune responses and cell death pathways. They are enriched in extracellular vesicles, suggesting utility as biomarkers and therapeutic agents, particularly in conditions like coronary artery disease and hypertrophic cardiomyopathy.

Equally compelling are the roles of snoRNAs and snRNAs, which modulate ribosomal function, RNA methylation, and mRNA splicing. Dysregulation of these molecules correlates with adverse cardiovascular events, from vascular remodeling to electrophysiological imbalances in myocardial tissue.

Collectively, these findings open new frontiers in cardiovascular medicine. The distinct expression patterns and mechanisms of sncRNAs underscore their diagnostic and therapeutic potential.

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Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis is placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.
Scopus CiteScore: 7.3
Impact Factor: 6.9

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Print ISSN: 2352-4820
eISSN: 2352-3042
CN: 50-1221/R
Contact Us: editor@genesndiseases.com
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Reference
Hemanyun Bai, Fanji Meng, Kangling Ke, Lingyan Fang, Weize Xu, Haitao Huang, Xiao Liang, Weiyan Li, Fengya Zeng, Can Chen, The significance of small noncoding RNAs in the pathogenesis of cardiovascular diseases, Genes & Diseases, Volume 12, Issue 4, 2025, 101342, https://doi.org/10.1016/j.gendis.2024.101342

Funding Information:
Zhanjiang Science and Technology Plan Project 2022A01143
Zhanjiang Science and Technology Plan Project 2023E0005
Zhanjiang Science and Technology Plan Project 2022A01149
Zhanjiang Science and Technology Plan Project 2021A05094
Discipline Construction Project of Guangdong Medical University GDMXK2021001
Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine 20232213
Postdoctoral Research Project of the Second Affiliated Hospital of Guangdong Medical University 22H01

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EBC Financial Group Strengthens LATAM Presence at iFX EXPO 2025, Reinforces Commitment to Inclusive Trading

David Barrett, CEO of EBC Financial Group (UK) Ltd, takes the mic at iFX Expo LATAM 2025 to decode what lies ahead for traders navigating a rapidly shifting global economy.Diego Sosa, Country Manager of EBC Financial Group in Mexico, joins top voices in LATAM to explore e-trading perspectives for 2025 – bullish or bearish?From financial literacy to platform access, EBC spotlights solutions tailored for LATAM’s rapidly developing investor landscape.MEXICO, April 22, 2025 /EINPresswire.com/ -- EBC Financial Group (EBC) joined global thought leaders, fintech players, and regional brokers at iFX EXPO LATAM 2025 to explore how Latin America can unlock smarter, more inclusive participation in global markets. With Mexico’s retail investor penetration still under 10%, EBC leaned into conversations around trust, access, and the role of education in fostering long-term financial resilience — with each session and engagement focused on empowering the next wave of informed and confident traders. 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Facing volatility with strategy, not fear At the expo, David Barrett, CEO of EBC Financial Group (UK) Ltd, joined the panel “The Ultimate LATAM & Global Market Outlook 2025”, where he addressed the factors that are defining regional and international markets: currency volatility, changes in interest rates, and geopolitical uncertainty. “The recent market turbulence reminds us that resilience and adaptability are more crucial than ever,” said Barrett. “Volatility isn’t something to fear — it’s something to understand and navigate with discipline. At EBC, we’re focused on giving traders the tools and education they need to make confident decisions, even in uncertain conditions.” Barrett’s participation also highlighted EBC’s interest in building a deeper presence across Latin America — not just as a trading platform provider, but as a source of macroeconomic insight and collaborative learning. With volatility increasingly becoming a defining feature of modern markets, EBC is focused on equipping traders with long-term frameworks that help them stay ahead. Disciplined trading in a shifting reality In the panel "E-Trading Outlook 2025: A Bull Run or a Bear Struggle?", Diego Sosa, Country Manager of EBC Financial Group in Mexico, shared his perspective on how investors can maintain their outlook amid market volatility and trade tensions between Mexico and the United States. “In an environment shaped by volatility and trade tensions between Mexico and the U.S., it’s critical for investors to have strategic tools for protection. Using instruments like Contracts for Difference (CFDs) in a disciplined manner allows for agile responses to unexpected changes without falling into reactive decision-making. The key lies in having a well-informed strategy based on macroeconomic analysis and risk management.” His remarks highlighted EBC’s ongoing focus on trader education, thoughtful risk strategies, and accessible tools for navigating unpredictable markets. Sosa also pointed to the growing sophistication of LATAM investors. “We’re seeing more interest in diversified instruments and multi-asset strategies—people want more than just access; they want smart access. That’s where EBC steps in,” he noted. On the ground: Connecting with LATAM’s financial community During the event, EBC held in-depth discussions with market participants eager to explore smarter tools and regionally relevant support. From brokers to first-time traders, the team engaged a wide cross-section of the financial community. These interactions also served as valuable touchpoints for EBC to identify potential collaboration with educational institutions, fintech developers, and local brokers — opening doors for co-creating solutions that address the region’s specific market barriers. Beyond the expo: Strengthening trust and access across LATAM With regulatory oversight from the FCA (UK), ASIC (Australia), CIMA (Cayman Islands) and FSC (Mauritius), EBC continues to focus on building trust through education, responsible trading practices, and investor protection — priorities that resonate deeply in fast-developing markets like Latin America. “Investing isn’t just about capital — it’s about trust and knowledge,” said José Manuel Herrera, EBC Financial Group’s Regional Manager for Latin America. “Our role is to help people make more informed decisions and gain access to tools that once felt out of reach. Events like this are an opportunity to listen, learn, and exchange ideas that enrich the financial community.” As EBC looks beyond Mexico, efforts are already underway to explore market entry opportunities in countries such as Colombia, Chile, and Argentina — each offering distinct growth potential. Local presence, multilingual support, and culturally relevant content will continue to shape the Group’s approach to regional expansion. That same spirit guides EBC’s global initiative, the Million Dollar Trading Challenge (MDTC), designed to give real traders the opportunity to develop strategies, refine their skills, and compete in a regulated environment. By offering participants the opportunity to test different approaches, sharpen their real-time decision-making, and compete in a regulated environment, the challenge reflects EBC’s belief that financial literacy should be practical, inclusive, and widely available. EBC’s presence at iFX EXPO LATAM 2025 goes beyond a single market entry. It reaffirms the Group’s long-term ambition to embed itself in the financial fabric of Latin America — through localised support, strategic alliances, and a shared vision of enabling sustainable investor success. Whether it’s through regional talent development, educational initiatives, or next-gen platforms, EBC remains committed to shaping a more inclusive and empowered trading ecosystem across the region. For more information about EBC Financial Group, visit: https://www.ebc.com/.
EIN Newswire BRAK ZDJĘCIA
2025-04-22 | 10:55:05

EBC Financial Group Strengthens LATAM Presence at iFX EXPO 2025, Reinforces Commitment to Inclusive Trading

David Barrett, CEO of EBC Financial Group (UK) Ltd, takes the mic at iFX Expo LATAM 2025 to decode what lies ahead for traders navigating a rapidly shifting global economy.Diego Sosa, Country Manager of EBC Financial Group in Mexico, joins top voices in LATAM to explore e-trading perspectives for 2025 – bullish or bearish?From financial literacy to platform access, EBC spotlights solutions tailored for LATAM’s rapidly developing investor landscape.MEXICO, April 22, 2025 /EINPresswire.com/ -- EBC Financial Group (EBC) joined global thought leaders, fintech players, and regional brokers at iFX EXPO LATAM 2025 to explore how Latin America can unlock smarter, more inclusive participation in global markets. With Mexico’s retail investor penetration still under 10%, EBC leaned into conversations around trust, access, and the role of education in fostering long-term financial resilience — with each session and engagement focused on empowering the next wave of informed and confident traders. EBC’s entry into Mexico comes at a pivotal moment, with interest in self-directed trading and alternative investments gaining ground across Latin America. The expo offered a timely opportunity to engage with a wide range of market players — from seasoned professionals to new retail entrants — many of whom are navigating an increasingly complex financial landscape. Their perspectives enriched the discussion panels, especially those focused on global dynamics and their impact on the region. Facing volatility with strategy, not fear At the expo, David Barrett, CEO of EBC Financial Group (UK) Ltd, joined the panel “The Ultimate LATAM & Global Market Outlook 2025”, where he addressed the factors that are defining regional and international markets: currency volatility, changes in interest rates, and geopolitical uncertainty. “The recent market turbulence reminds us that resilience and adaptability are more crucial than ever,” said Barrett. “Volatility isn’t something to fear — it’s something to understand and navigate with discipline. At EBC, we’re focused on giving traders the tools and education they need to make confident decisions, even in uncertain conditions.” Barrett’s participation also highlighted EBC’s interest in building a deeper presence across Latin America — not just as a trading platform provider, but as a source of macroeconomic insight and collaborative learning. With volatility increasingly becoming a defining feature of modern markets, EBC is focused on equipping traders with long-term frameworks that help them stay ahead. Disciplined trading in a shifting reality In the panel "E-Trading Outlook 2025: A Bull Run or a Bear Struggle?", Diego Sosa, Country Manager of EBC Financial Group in Mexico, shared his perspective on how investors can maintain their outlook amid market volatility and trade tensions between Mexico and the United States. “In an environment shaped by volatility and trade tensions between Mexico and the U.S., it’s critical for investors to have strategic tools for protection. Using instruments like Contracts for Difference (CFDs) in a disciplined manner allows for agile responses to unexpected changes without falling into reactive decision-making. The key lies in having a well-informed strategy based on macroeconomic analysis and risk management.” His remarks highlighted EBC’s ongoing focus on trader education, thoughtful risk strategies, and accessible tools for navigating unpredictable markets. Sosa also pointed to the growing sophistication of LATAM investors. “We’re seeing more interest in diversified instruments and multi-asset strategies—people want more than just access; they want smart access. That’s where EBC steps in,” he noted. On the ground: Connecting with LATAM’s financial community During the event, EBC held in-depth discussions with market participants eager to explore smarter tools and regionally relevant support. From brokers to first-time traders, the team engaged a wide cross-section of the financial community. These interactions also served as valuable touchpoints for EBC to identify potential collaboration with educational institutions, fintech developers, and local brokers — opening doors for co-creating solutions that address the region’s specific market barriers. Beyond the expo: Strengthening trust and access across LATAM With regulatory oversight from the FCA (UK), ASIC (Australia), CIMA (Cayman Islands) and FSC (Mauritius), EBC continues to focus on building trust through education, responsible trading practices, and investor protection — priorities that resonate deeply in fast-developing markets like Latin America. “Investing isn’t just about capital — it’s about trust and knowledge,” said José Manuel Herrera, EBC Financial Group’s Regional Manager for Latin America. “Our role is to help people make more informed decisions and gain access to tools that once felt out of reach. Events like this are an opportunity to listen, learn, and exchange ideas that enrich the financial community.” As EBC looks beyond Mexico, efforts are already underway to explore market entry opportunities in countries such as Colombia, Chile, and Argentina — each offering distinct growth potential. Local presence, multilingual support, and culturally relevant content will continue to shape the Group’s approach to regional expansion. That same spirit guides EBC’s global initiative, the Million Dollar Trading Challenge (MDTC), designed to give real traders the opportunity to develop strategies, refine their skills, and compete in a regulated environment. By offering participants the opportunity to test different approaches, sharpen their real-time decision-making, and compete in a regulated environment, the challenge reflects EBC’s belief that financial literacy should be practical, inclusive, and widely available. EBC’s presence at iFX EXPO LATAM 2025 goes beyond a single market entry. It reaffirms the Group’s long-term ambition to embed itself in the financial fabric of Latin America — through localised support, strategic alliances, and a shared vision of enabling sustainable investor success. Whether it’s through regional talent development, educational initiatives, or next-gen platforms, EBC remains committed to shaping a more inclusive and empowered trading ecosystem across the region. For more information about EBC Financial Group, visit: https://www.ebc.com/.

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