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New Insights into Cancer Biology: The Dual Role of FMRP in Tumor Progression and Therapy Resistance

2025-04-20  |  15:55:05
THEROLE1

Multi-domain structure of FMRP. Tandem Tudor domains are located at the N-terminus of FMRP; these domains (depicted in yellow) enable specific recognition and binding to proteins with methylated lysine residues, crucial for epigenetic modulation and RNA p

THEROLE2

Biological functions of FMRP in RNA biology. The illustrations depict the functional mechanisms of FMRP (depicted in the center) in RNA biology, such as miRNA/cirRNA/lncRNA-mediated regulation, mRNA transport and localization, RNA modification (m5C/5-meth

THEROLE3

The pivotal role of FMRP in cancer development and progression. High FMRP levels are associated with enhanced invasiveness, metastasis, and drug resistance as well as contributing to the cancer's ability to evade immune surveillance and promote angiogenes

SHANNON, CLARE, IRELAND, April 20, 2025 /EINPresswire.com/ -- A recent review published in Genes & Diseases sheds light on the complex and multifaceted role of RNA-binding proteins (RBPs) in cancer progression, with a particular focus on the fragile X mental retardation protein (FMRP). Traditionally recognized for its critical functions in neural development, FMRP is now emerging as a key regulator in cancer biology, influencing tumor growth, metastasis, and therapy resistance. This growing body of knowledge presents a shift in understanding how RNA metabolism can drive oncogenic processes and potentially offer novel diagnostic and therapeutic strategies.

FMRP plays a dual role in cancer, acting both as a tumor suppressor and promoter, depending on the cellular context. Its ability to regulate mRNA stability, translation, and transport positions it as a crucial factor in the intricate network of gene expression that governs cancer progression. Studies indicate that low levels of FMRP are associated with decreased tumor development in some cases, whereas high expression is linked to aggressive cancers, including breast, colorectal, and hepatocellular carcinomas. The variability in FMRP’s impact on different tumor types underscores the necessity for a nuanced approach when considering it as a therapeutic target.

One of the most significant findings discussed in the review is FMRP’s role in therapy resistance. By interacting with key oncogenic pathways, FMRP contributes to cancer cells' ability to withstand chemotherapy, radiation, and immunotherapy. In colorectal cancer, FMRP stabilizes epidermal growth factor receptor (EGFR) mRNA, enhancing tumor proliferation. Additionally, its involvement in epithelial-mesenchymal transition (EMT) suggests a critical function in tumor metastasis. Furthermore, its association with immune evasion mechanisms highlights its potential influence on the tumor microenvironment and response to immune checkpoint inhibitors.

The potential of targeting FMRP in cancer treatment is an area of growing interest. By interfering with its ability to regulate oncogenic mRNAs, researchers aim to develop precision medicine strategies that can either inhibit its tumor-promoting functions or harness its tumor-suppressive capabilities. Exploring the post-translational modifications (PTMs) of FMRP and its interplay with other RNA-binding proteins could pave the way for highly specific therapeutic interventions that mitigate its oncogenic effects while preserving essential cellular functions.

This evolving understanding of FMRP’s role in cancer underscores the complexity of RNA metabolism in tumorigenesis. As scientists continue to investigate the intricate balance between FMRP’s tumor-suppressive and oncogenic functions, its potential as both a biomarker and therapeutic target is becoming increasingly evident.

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Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis is placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.
Scopus CiteScore: 7.3
Impact Factor: 6.9

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More information: https://www.keaipublishing.com/en/journals/genes-and-diseases/
Editorial Board: https://www.keaipublishing.com/en/journals/genes-and-diseases/editorial-board/
All issues and articles in press are available online in ScienceDirect (https://www.sciencedirect.com/journal/genes-and-diseases ).
Submissions to Genes & Disease may be made using Editorial Manager (https://www.editorialmanager.com/gendis/default.aspx ).
Print ISSN: 2352-4820
eISSN: 2352-3042
CN: 50-1221/R
Contact Us: editor@genesndiseases.com
X (formerly Twitter): @GenesNDiseases (https://x.com/GenesNDiseases )

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Reference
Yunlu Jia, Ruyin Jia, Yongxia Chen, Xuanyi Lin, Nadire Aishan, Han li, Linbo Wang, Xiaochen Zhang, Jian Ruan, The role of RNA binding proteins in cancer biology: A focus on FMRP, Genes & Diseases,
2025, 101493, https://doi.org/10.1016/j.gendis.2024.101493

Funding Information:
National Natural Science Foundation of China 82000212
Natural Science Foundation of Zhejiang Province, China LQ21H160022
Medical Health Science and Technology Project of Zhejiang Provincial Health Commission (China) 2024KY989

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EBC Financial Group Strengthens LATAM Presence at iFX EXPO 2025, Reinforces Commitment to Inclusive Trading

David Barrett, CEO of EBC Financial Group (UK) Ltd, takes the mic at iFX Expo LATAM 2025 to decode what lies ahead for traders navigating a rapidly shifting global economy.Diego Sosa, Country Manager of EBC Financial Group in Mexico, joins top voices in LATAM to explore e-trading perspectives for 2025 – bullish or bearish?From financial literacy to platform access, EBC spotlights solutions tailored for LATAM’s rapidly developing investor landscape.MEXICO, April 22, 2025 /EINPresswire.com/ -- EBC Financial Group (EBC) joined global thought leaders, fintech players, and regional brokers at iFX EXPO LATAM 2025 to explore how Latin America can unlock smarter, more inclusive participation in global markets. With Mexico’s retail investor penetration still under 10%, EBC leaned into conversations around trust, access, and the role of education in fostering long-term financial resilience — with each session and engagement focused on empowering the next wave of informed and confident traders. 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With volatility increasingly becoming a defining feature of modern markets, EBC is focused on equipping traders with long-term frameworks that help them stay ahead. Disciplined trading in a shifting reality In the panel "E-Trading Outlook 2025: A Bull Run or a Bear Struggle?", Diego Sosa, Country Manager of EBC Financial Group in Mexico, shared his perspective on how investors can maintain their outlook amid market volatility and trade tensions between Mexico and the United States. “In an environment shaped by volatility and trade tensions between Mexico and the U.S., it’s critical for investors to have strategic tools for protection. Using instruments like Contracts for Difference (CFDs) in a disciplined manner allows for agile responses to unexpected changes without falling into reactive decision-making. The key lies in having a well-informed strategy based on macroeconomic analysis and risk management.” His remarks highlighted EBC’s ongoing focus on trader education, thoughtful risk strategies, and accessible tools for navigating unpredictable markets. Sosa also pointed to the growing sophistication of LATAM investors. “We’re seeing more interest in diversified instruments and multi-asset strategies—people want more than just access; they want smart access. That’s where EBC steps in,” he noted. On the ground: Connecting with LATAM’s financial community During the event, EBC held in-depth discussions with market participants eager to explore smarter tools and regionally relevant support. From brokers to first-time traders, the team engaged a wide cross-section of the financial community. These interactions also served as valuable touchpoints for EBC to identify potential collaboration with educational institutions, fintech developers, and local brokers — opening doors for co-creating solutions that address the region’s specific market barriers. Beyond the expo: Strengthening trust and access across LATAM With regulatory oversight from the FCA (UK), ASIC (Australia), CIMA (Cayman Islands) and FSC (Mauritius), EBC continues to focus on building trust through education, responsible trading practices, and investor protection — priorities that resonate deeply in fast-developing markets like Latin America. “Investing isn’t just about capital — it’s about trust and knowledge,” said José Manuel Herrera, EBC Financial Group’s Regional Manager for Latin America. “Our role is to help people make more informed decisions and gain access to tools that once felt out of reach. Events like this are an opportunity to listen, learn, and exchange ideas that enrich the financial community.” As EBC looks beyond Mexico, efforts are already underway to explore market entry opportunities in countries such as Colombia, Chile, and Argentina — each offering distinct growth potential. Local presence, multilingual support, and culturally relevant content will continue to shape the Group’s approach to regional expansion. That same spirit guides EBC’s global initiative, the Million Dollar Trading Challenge (MDTC), designed to give real traders the opportunity to develop strategies, refine their skills, and compete in a regulated environment. By offering participants the opportunity to test different approaches, sharpen their real-time decision-making, and compete in a regulated environment, the challenge reflects EBC’s belief that financial literacy should be practical, inclusive, and widely available. EBC’s presence at iFX EXPO LATAM 2025 goes beyond a single market entry. It reaffirms the Group’s long-term ambition to embed itself in the financial fabric of Latin America — through localised support, strategic alliances, and a shared vision of enabling sustainable investor success. Whether it’s through regional talent development, educational initiatives, or next-gen platforms, EBC remains committed to shaping a more inclusive and empowered trading ecosystem across the region. For more information about EBC Financial Group, visit: https://www.ebc.com/.
EIN Newswire BRAK ZDJĘCIA
2025-04-22 | 10:55:05

EBC Financial Group Strengthens LATAM Presence at iFX EXPO 2025, Reinforces Commitment to Inclusive Trading

David Barrett, CEO of EBC Financial Group (UK) Ltd, takes the mic at iFX Expo LATAM 2025 to decode what lies ahead for traders navigating a rapidly shifting global economy.Diego Sosa, Country Manager of EBC Financial Group in Mexico, joins top voices in LATAM to explore e-trading perspectives for 2025 – bullish or bearish?From financial literacy to platform access, EBC spotlights solutions tailored for LATAM’s rapidly developing investor landscape.MEXICO, April 22, 2025 /EINPresswire.com/ -- EBC Financial Group (EBC) joined global thought leaders, fintech players, and regional brokers at iFX EXPO LATAM 2025 to explore how Latin America can unlock smarter, more inclusive participation in global markets. With Mexico’s retail investor penetration still under 10%, EBC leaned into conversations around trust, access, and the role of education in fostering long-term financial resilience — with each session and engagement focused on empowering the next wave of informed and confident traders. EBC’s entry into Mexico comes at a pivotal moment, with interest in self-directed trading and alternative investments gaining ground across Latin America. The expo offered a timely opportunity to engage with a wide range of market players — from seasoned professionals to new retail entrants — many of whom are navigating an increasingly complex financial landscape. Their perspectives enriched the discussion panels, especially those focused on global dynamics and their impact on the region. Facing volatility with strategy, not fear At the expo, David Barrett, CEO of EBC Financial Group (UK) Ltd, joined the panel “The Ultimate LATAM & Global Market Outlook 2025”, where he addressed the factors that are defining regional and international markets: currency volatility, changes in interest rates, and geopolitical uncertainty. “The recent market turbulence reminds us that resilience and adaptability are more crucial than ever,” said Barrett. “Volatility isn’t something to fear — it’s something to understand and navigate with discipline. At EBC, we’re focused on giving traders the tools and education they need to make confident decisions, even in uncertain conditions.” Barrett’s participation also highlighted EBC’s interest in building a deeper presence across Latin America — not just as a trading platform provider, but as a source of macroeconomic insight and collaborative learning. With volatility increasingly becoming a defining feature of modern markets, EBC is focused on equipping traders with long-term frameworks that help them stay ahead. Disciplined trading in a shifting reality In the panel "E-Trading Outlook 2025: A Bull Run or a Bear Struggle?", Diego Sosa, Country Manager of EBC Financial Group in Mexico, shared his perspective on how investors can maintain their outlook amid market volatility and trade tensions between Mexico and the United States. “In an environment shaped by volatility and trade tensions between Mexico and the U.S., it’s critical for investors to have strategic tools for protection. Using instruments like Contracts for Difference (CFDs) in a disciplined manner allows for agile responses to unexpected changes without falling into reactive decision-making. The key lies in having a well-informed strategy based on macroeconomic analysis and risk management.” His remarks highlighted EBC’s ongoing focus on trader education, thoughtful risk strategies, and accessible tools for navigating unpredictable markets. Sosa also pointed to the growing sophistication of LATAM investors. “We’re seeing more interest in diversified instruments and multi-asset strategies—people want more than just access; they want smart access. That’s where EBC steps in,” he noted. On the ground: Connecting with LATAM’s financial community During the event, EBC held in-depth discussions with market participants eager to explore smarter tools and regionally relevant support. From brokers to first-time traders, the team engaged a wide cross-section of the financial community. These interactions also served as valuable touchpoints for EBC to identify potential collaboration with educational institutions, fintech developers, and local brokers — opening doors for co-creating solutions that address the region’s specific market barriers. Beyond the expo: Strengthening trust and access across LATAM With regulatory oversight from the FCA (UK), ASIC (Australia), CIMA (Cayman Islands) and FSC (Mauritius), EBC continues to focus on building trust through education, responsible trading practices, and investor protection — priorities that resonate deeply in fast-developing markets like Latin America. “Investing isn’t just about capital — it’s about trust and knowledge,” said José Manuel Herrera, EBC Financial Group’s Regional Manager for Latin America. “Our role is to help people make more informed decisions and gain access to tools that once felt out of reach. Events like this are an opportunity to listen, learn, and exchange ideas that enrich the financial community.” As EBC looks beyond Mexico, efforts are already underway to explore market entry opportunities in countries such as Colombia, Chile, and Argentina — each offering distinct growth potential. Local presence, multilingual support, and culturally relevant content will continue to shape the Group’s approach to regional expansion. That same spirit guides EBC’s global initiative, the Million Dollar Trading Challenge (MDTC), designed to give real traders the opportunity to develop strategies, refine their skills, and compete in a regulated environment. By offering participants the opportunity to test different approaches, sharpen their real-time decision-making, and compete in a regulated environment, the challenge reflects EBC’s belief that financial literacy should be practical, inclusive, and widely available. EBC’s presence at iFX EXPO LATAM 2025 goes beyond a single market entry. It reaffirms the Group’s long-term ambition to embed itself in the financial fabric of Latin America — through localised support, strategic alliances, and a shared vision of enabling sustainable investor success. Whether it’s through regional talent development, educational initiatives, or next-gen platforms, EBC remains committed to shaping a more inclusive and empowered trading ecosystem across the region. For more information about EBC Financial Group, visit: https://www.ebc.com/.

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