Komunikaty PR

R-Loops Play Dual Role in Genome Stability and Disease

2025-04-20  |  15:55:05
UPDAT1

The factors contributing to R-loop formation. Several factors contribute to R-loop formation, including RNA components, specific DNA structures, histone and RNA modifications, RNA-binding proteins, and helicases.

UPDAT2

Mystery of RNA:DNA hybrid formation at double-strand break (DSB) site.

UPDAT3

R-loop mediated immune response.

SHANNON, CLARE, IRELAND, April 20, 2025 /EINPresswire.com/ --
This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it. These three-stranded nucleic acid structures, composed of an RNA:DNA hybrid and a displaced DNA strand, are now recognized not merely as byproducts of transcription but as essential regulatory elements in gene expression, DNA replication, and repair mechanisms.

The article traces the evolution of R-loop research, illuminating how sophisticated detection techniques have transformed our understanding of their biological functions. From early antibody-based imaging to high-throughput sequencing methods like DRIP-seq and R-ChIP, the field has advanced rapidly. These tools have revealed the extensive presence of R-loops at key genomic regions such as promoters, terminators, and double-strand break (DSB) sites, positioning them as significant actors in the DNA damage response.

A central focus of the article is the dual nature of R-loops. Under controlled conditions, they play protective roles—regulating gene activity, terminating transcription, and facilitating repair through homologous recombination. However, when dysregulated, R-loops become hazardous. They can obstruct replication forks, induce transcription-replication collisions, and provoke DSBs, ultimately threatening genome integrity. These pathological consequences are amplified in the context of mutations in repair-related genes like BRCA1 and BRCA2, underlining their relevance in diseases such as cancer and neurodegeneration.

The article draws attention to the influence of non-coding RNAs, including lncRNAs, circRNAs, and enhancer RNAs, in modulating R-loop formation. These RNA species can either stabilize or destabilize R-loops, thus influencing chromatin structure and transcriptional dynamics. Additionally, the interplay between R-loops and RNA modifications like m6A and m5C further adds to the complexity of their biological impact, especially in DNA repair pathways.

The emerging connection between R-loops and immune responses are also explored, showing how they can activate pathways like cGAS-STING, linking genomic surveillance to inflammatory signaling. This cross-disciplinary significance makes R-loops a promising frontier for therapeutic intervention, especially in diseases driven by genome instability.


# # # # #
Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis is placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.
Scopus CiteScore: 7.3
Impact Factor: 6.9

# # # # # #

More information: https://www.keaipublishing.com/en/journals/genes-and-diseases/
Editorial Board: https://www.keaipublishing.com/en/journals/genes-and-diseases/editorial-board/
All issues and articles in press are available online in ScienceDirect (https://www.sciencedirect.com/journal/genes-and-diseases ).
Submissions to Genes & Disease may be made using Editorial Manager (https://www.editorialmanager.com/gendis/default.aspx ).
Print ISSN: 2352-4820
eISSN: 2352-3042
CN: 50-1221/R
Contact Us: editor@genesndiseases.com
X (formerly Twitter): @GenesNDiseases (https://x.com/GenesNDiseases )

# # # # # #
Reference
Min Zhu, Xinyu Wang, Hongchang Zhao, Zhenjie Wang, Update on R-loops in genomic integrity: Formation, functions, and implications for human diseases, Genes & Diseases, Volume 12, Issue 4, 2025, 101401, https://doi.org/10.1016/j.gendis.2024.101401

Funding Information:
National Natural Science Foundation of China 32201061
Natural Science Foundation of Shandong, China ZR2021QC083

Genes & Diseases Editorial Office
Genes & Diseases
+86 23 6571 4691
editor|genesndiseases.com| |editor|genesndiseases.com

Legal Disclaimer:

EIN Presswire provides this news content "as is" without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.

Newseria nie ponosi odpowiedzialności za treści oraz inne materiały (np. infografiki, zdjęcia) przekazywane w „Biurze Prasowym”, których autorami są zarejestrowani użytkownicy tacy jak agencje PR, firmy czy instytucje państwowe.
Ostatnio dodane
komunikaty PR z wybranej przez Ciebie kategorii
EIN Newswire BRAK ZDJĘCIA
2025-04-22 | 10:55:05

Wine and Beverage Refrigerator Market USD 4.63 Billion by 2032, at 5.04% CAGR, Driven by Changing Consumer Lifestyles

Rising home investments and interest in wine culture are driving demand for wine fridges, blending function with lifestyle and home-based leisure trends NEW YORK, NY, UNITED STATES, April 22, 2025 /EINPresswire.com/ --
EIN Newswire BRAK ZDJĘCIA
2025-04-22 | 10:55:05

EBC Financial Group Strengthens LATAM Presence at iFX EXPO 2025, Reinforces Commitment to Inclusive Trading

David Barrett, CEO of EBC Financial Group (UK) Ltd, takes the mic at iFX Expo LATAM 2025 to decode what lies ahead for traders navigating a rapidly shifting global economy.Diego Sosa, Country Manager of EBC Financial Group in Mexico, joins top voices in LATAM to explore e-trading perspectives for 2025 – bullish or bearish?From financial literacy to platform access, EBC spotlights solutions tailored for LATAM’s rapidly developing investor landscape.MEXICO, April 22, 2025 /EINPresswire.com/ -- EBC Financial Group (EBC) joined global thought leaders, fintech players, and regional brokers at iFX EXPO LATAM 2025 to explore how Latin America can unlock smarter, more inclusive participation in global markets. With Mexico’s retail investor penetration still under 10%, EBC leaned into conversations around trust, access, and the role of education in fostering long-term financial resilience — with each session and engagement focused on empowering the next wave of informed and confident traders. EBC’s entry into Mexico comes at a pivotal moment, with interest in self-directed trading and alternative investments gaining ground across Latin America. The expo offered a timely opportunity to engage with a wide range of market players — from seasoned professionals to new retail entrants — many of whom are navigating an increasingly complex financial landscape. Their perspectives enriched the discussion panels, especially those focused on global dynamics and their impact on the region. Facing volatility with strategy, not fear At the expo, David Barrett, CEO of EBC Financial Group (UK) Ltd, joined the panel “The Ultimate LATAM & Global Market Outlook 2025”, where he addressed the factors that are defining regional and international markets: currency volatility, changes in interest rates, and geopolitical uncertainty. “The recent market turbulence reminds us that resilience and adaptability are more crucial than ever,” said Barrett. “Volatility isn’t something to fear — it’s something to understand and navigate with discipline. At EBC, we’re focused on giving traders the tools and education they need to make confident decisions, even in uncertain conditions.” Barrett’s participation also highlighted EBC’s interest in building a deeper presence across Latin America — not just as a trading platform provider, but as a source of macroeconomic insight and collaborative learning. With volatility increasingly becoming a defining feature of modern markets, EBC is focused on equipping traders with long-term frameworks that help them stay ahead. Disciplined trading in a shifting reality In the panel "E-Trading Outlook 2025: A Bull Run or a Bear Struggle?", Diego Sosa, Country Manager of EBC Financial Group in Mexico, shared his perspective on how investors can maintain their outlook amid market volatility and trade tensions between Mexico and the United States. “In an environment shaped by volatility and trade tensions between Mexico and the U.S., it’s critical for investors to have strategic tools for protection. Using instruments like Contracts for Difference (CFDs) in a disciplined manner allows for agile responses to unexpected changes without falling into reactive decision-making. The key lies in having a well-informed strategy based on macroeconomic analysis and risk management.” His remarks highlighted EBC’s ongoing focus on trader education, thoughtful risk strategies, and accessible tools for navigating unpredictable markets. Sosa also pointed to the growing sophistication of LATAM investors. “We’re seeing more interest in diversified instruments and multi-asset strategies—people want more than just access; they want smart access. That’s where EBC steps in,” he noted. On the ground: Connecting with LATAM’s financial community During the event, EBC held in-depth discussions with market participants eager to explore smarter tools and regionally relevant support. From brokers to first-time traders, the team engaged a wide cross-section of the financial community. These interactions also served as valuable touchpoints for EBC to identify potential collaboration with educational institutions, fintech developers, and local brokers — opening doors for co-creating solutions that address the region’s specific market barriers. Beyond the expo: Strengthening trust and access across LATAM With regulatory oversight from the FCA (UK), ASIC (Australia), CIMA (Cayman Islands) and FSC (Mauritius), EBC continues to focus on building trust through education, responsible trading practices, and investor protection — priorities that resonate deeply in fast-developing markets like Latin America. “Investing isn’t just about capital — it’s about trust and knowledge,” said José Manuel Herrera, EBC Financial Group’s Regional Manager for Latin America. “Our role is to help people make more informed decisions and gain access to tools that once felt out of reach. Events like this are an opportunity to listen, learn, and exchange ideas that enrich the financial community.” As EBC looks beyond Mexico, efforts are already underway to explore market entry opportunities in countries such as Colombia, Chile, and Argentina — each offering distinct growth potential. Local presence, multilingual support, and culturally relevant content will continue to shape the Group’s approach to regional expansion. That same spirit guides EBC’s global initiative, the Million Dollar Trading Challenge (MDTC), designed to give real traders the opportunity to develop strategies, refine their skills, and compete in a regulated environment. By offering participants the opportunity to test different approaches, sharpen their real-time decision-making, and compete in a regulated environment, the challenge reflects EBC’s belief that financial literacy should be practical, inclusive, and widely available. EBC’s presence at iFX EXPO LATAM 2025 goes beyond a single market entry. It reaffirms the Group’s long-term ambition to embed itself in the financial fabric of Latin America — through localised support, strategic alliances, and a shared vision of enabling sustainable investor success. Whether it’s through regional talent development, educational initiatives, or next-gen platforms, EBC remains committed to shaping a more inclusive and empowered trading ecosystem across the region. For more information about EBC Financial Group, visit: https://www.ebc.com/.
EIN Newswire BRAK ZDJĘCIA
2025-04-22 | 10:55:05

EBC Financial Group Strengthens LATAM Presence at iFX EXPO 2025, Reinforces Commitment to Inclusive Trading

David Barrett, CEO of EBC Financial Group (UK) Ltd, takes the mic at iFX Expo LATAM 2025 to decode what lies ahead for traders navigating a rapidly shifting global economy.Diego Sosa, Country Manager of EBC Financial Group in Mexico, joins top voices in LATAM to explore e-trading perspectives for 2025 – bullish or bearish?From financial literacy to platform access, EBC spotlights solutions tailored for LATAM’s rapidly developing investor landscape.MEXICO, April 22, 2025 /EINPresswire.com/ -- EBC Financial Group (EBC) joined global thought leaders, fintech players, and regional brokers at iFX EXPO LATAM 2025 to explore how Latin America can unlock smarter, more inclusive participation in global markets. With Mexico’s retail investor penetration still under 10%, EBC leaned into conversations around trust, access, and the role of education in fostering long-term financial resilience — with each session and engagement focused on empowering the next wave of informed and confident traders. EBC’s entry into Mexico comes at a pivotal moment, with interest in self-directed trading and alternative investments gaining ground across Latin America. The expo offered a timely opportunity to engage with a wide range of market players — from seasoned professionals to new retail entrants — many of whom are navigating an increasingly complex financial landscape. Their perspectives enriched the discussion panels, especially those focused on global dynamics and their impact on the region. Facing volatility with strategy, not fear At the expo, David Barrett, CEO of EBC Financial Group (UK) Ltd, joined the panel “The Ultimate LATAM & Global Market Outlook 2025”, where he addressed the factors that are defining regional and international markets: currency volatility, changes in interest rates, and geopolitical uncertainty. “The recent market turbulence reminds us that resilience and adaptability are more crucial than ever,” said Barrett. “Volatility isn’t something to fear — it’s something to understand and navigate with discipline. At EBC, we’re focused on giving traders the tools and education they need to make confident decisions, even in uncertain conditions.” Barrett’s participation also highlighted EBC’s interest in building a deeper presence across Latin America — not just as a trading platform provider, but as a source of macroeconomic insight and collaborative learning. With volatility increasingly becoming a defining feature of modern markets, EBC is focused on equipping traders with long-term frameworks that help them stay ahead. Disciplined trading in a shifting reality In the panel "E-Trading Outlook 2025: A Bull Run or a Bear Struggle?", Diego Sosa, Country Manager of EBC Financial Group in Mexico, shared his perspective on how investors can maintain their outlook amid market volatility and trade tensions between Mexico and the United States. “In an environment shaped by volatility and trade tensions between Mexico and the U.S., it’s critical for investors to have strategic tools for protection. Using instruments like Contracts for Difference (CFDs) in a disciplined manner allows for agile responses to unexpected changes without falling into reactive decision-making. The key lies in having a well-informed strategy based on macroeconomic analysis and risk management.” His remarks highlighted EBC’s ongoing focus on trader education, thoughtful risk strategies, and accessible tools for navigating unpredictable markets. Sosa also pointed to the growing sophistication of LATAM investors. “We’re seeing more interest in diversified instruments and multi-asset strategies—people want more than just access; they want smart access. That’s where EBC steps in,” he noted. On the ground: Connecting with LATAM’s financial community During the event, EBC held in-depth discussions with market participants eager to explore smarter tools and regionally relevant support. From brokers to first-time traders, the team engaged a wide cross-section of the financial community. These interactions also served as valuable touchpoints for EBC to identify potential collaboration with educational institutions, fintech developers, and local brokers — opening doors for co-creating solutions that address the region’s specific market barriers. Beyond the expo: Strengthening trust and access across LATAM With regulatory oversight from the FCA (UK), ASIC (Australia), CIMA (Cayman Islands) and FSC (Mauritius), EBC continues to focus on building trust through education, responsible trading practices, and investor protection — priorities that resonate deeply in fast-developing markets like Latin America. “Investing isn’t just about capital — it’s about trust and knowledge,” said José Manuel Herrera, EBC Financial Group’s Regional Manager for Latin America. “Our role is to help people make more informed decisions and gain access to tools that once felt out of reach. Events like this are an opportunity to listen, learn, and exchange ideas that enrich the financial community.” As EBC looks beyond Mexico, efforts are already underway to explore market entry opportunities in countries such as Colombia, Chile, and Argentina — each offering distinct growth potential. Local presence, multilingual support, and culturally relevant content will continue to shape the Group’s approach to regional expansion. That same spirit guides EBC’s global initiative, the Million Dollar Trading Challenge (MDTC), designed to give real traders the opportunity to develop strategies, refine their skills, and compete in a regulated environment. By offering participants the opportunity to test different approaches, sharpen their real-time decision-making, and compete in a regulated environment, the challenge reflects EBC’s belief that financial literacy should be practical, inclusive, and widely available. EBC’s presence at iFX EXPO LATAM 2025 goes beyond a single market entry. It reaffirms the Group’s long-term ambition to embed itself in the financial fabric of Latin America — through localised support, strategic alliances, and a shared vision of enabling sustainable investor success. Whether it’s through regional talent development, educational initiatives, or next-gen platforms, EBC remains committed to shaping a more inclusive and empowered trading ecosystem across the region. For more information about EBC Financial Group, visit: https://www.ebc.com/.

Kalendarium

Więcej ważnych informacji

Jedynka Newserii

Jedynka Newserii

Szkolenie Online IMM

Prawo

Problemy społeczne

Duża zmiana w organizacji pracy w firmach. Elastyczność wśród najważniejszych oczekiwań pracowników

Dotychczasowe modele organizacji pracy w firmach nie zawsze odpowiadają na wyzwania przyszłości. Ostatnie lata zmieniły zasady gry na rynku pracy i teraz elastyczność liczy się na nim bardziej niż kiedykolwiek wcześniej. Elastyczny model pracy staje się jednym z bardziej oczekiwanych benefitów, a dla firm jest to sposób na przyciągnięcie talentów. Kolejnym jest wykorzystanie innowacyjnych narzędzi technologicznych. To jednak wymaga zarówno od pracowników, jak i od pracodawców zaangażowania w ciągłe podnoszenie kompetencji.

Motoryzacja

Pożary pojazdów elektrycznych są rzadsze niż spalinowych. W powszechnym przekonaniu jest odwrotnie, bo brakuje edukacji

Trzydzieści pożarów aut elektrycznych i niemal 9,5 tys. pożarów aut spalinowych – to statystyki za ubiegły rok. Jak podkreślają eksperci, statystycznie pojazdy elektryczne płoną rzadziej niż spalinowe. W przeliczeniu na tysiąc zarejestrowanych pojazdów wskaźnik pożarów w przypadku elektryków wynosi 0,372, a w przypadku aut spalinowych 0,424. Specjaliści są zgodni co do tego, że w powszechnym obiegu brakuje rzetelnej wiedzy na temat samochodów elektrycznych i ich bezpieczeństwa pożarowego.

Partner serwisu

Instytut Monitorowania Mediów

Szkolenia

Akademia Newserii

Akademia Newserii to projekt, w ramach którego najlepsi polscy dziennikarze biznesowi, giełdowi oraz lifestylowi, a  także szkoleniowcy z wieloletnim doświadczeniem dzielą się swoją wiedzą nt. pracy z mediami.